Is Waterfall D-Mannose safe, even at large dose levels?
Yes, to the very best of our knowledge, and according to all research. D-mannose is an essential glyconutrient, rather than a ‘medicine’. It is in every cell in your body, and your body produces mannose naturally, just as we produce vitamins like C and D. Mannose is also in all sorts of things like blueberries, pineapple, and aloe vera. You eat it all the time in a lot of foods. You just don’t eat enough of it, which is why you get utis. Waterfall D-Mannose has no known adverse effects at normal or even high dose levels. But obviously, like with any foodstuff, (Eg: chocolate) you could make yourself sick with it by eating too much. Suggested maximum dose is 50 grams a day. But you wouldn’t normally need even close to that. But it’s been shown to be safe at continuous very high dose levels, and most people will not need more than 6 level teaspoons a day (10 grams), even for well developed infections.
From Invista.com “In humans, no adverse effects have been noted when oral doses of approximately 15 grams were administered at a time (about 10 level teaspoons). Even oral doses as extreme as 53 grams per day given over an 11-month period showed no adverse side effects. However, when excessively large amounts (35 grams per hour) of Mannose was injected intravenously continuously for 10 hours, human subjects did experience fatigue, anorexia, malaise, and massive uric acid crystalluria. “
If, for some reason, you want to take such huge doses of Waterfall D-Mannose , especially over an extended period, best to discuss this with your doctor or an experienced nutritionalist.
Our own experience is that if you take more than about 2 or 3 times the recommended measure of Waterfall D-Mannose, you only absorb part of it through the small intestine. The remainder passes though to the large intestine, and could cause some diarrhea, (because it will latch onto any pathogenic E.coli or Klebsiella it encounters there, and escort them out of your body).